AI + MULTI-OMICS  ➡  PRECISION ONCOLOGY

The Chiu Lab is an interdisciplinary team affiliated with the UPMC Hillman Cancer Center and Department of Medicine at the University of Pittsburgh. Our mission is to bridge cutting-edge computational algorithms to unmet needs in precision medicine. Read more about the PI.

Research Highlights

Highlight at AACR: GPT-4 and gene-drug interactions

Michael's presentation at the American Association for Cancer Research (AACR) Annual Meeting 2024 has been selected as a highlight by the NCI Division of Cancer Biology (DCB; @NCICancerBio). In this study, we prototyped an efficient and accurate GPT-4 tool for analyzing gene-drug interactions through scientific literature in collaboration. Watch the DCB's interview with Michael and read the abstract.

shinyDeepDR is a user-friendly tool designed for predicting anti-cancer drug sensitivity using deep learning. With the tool, users can effortlessly perform an in silico screening of 265 approved and investigational compounds by uploading mutation and/or gene expression data from a cancer sample. Read the article.

DepLink is a web server to identify genetic and pharmacologic perturbations that induce similar effects on cell viability or molecular changes. It integrates heterogeneous datasets of genome-wide CRISPR screens, high-throughput drug screens, and gene expression signatures of perturbations. Read the article.

BHI is the flagship conference of the IEEE-EMBS (IEEE Engineering in Medicine and Biology Society) and serves as a unique forum for informatics and computing in healthcare and life sciences. We organized the Educational Activities including tutorials, panels, and student travel awards supported by the NSF and the NIH.

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